论文标题
纤维组织对左心房局灶性心律不齐期间的电激活模式的影响很小
Fiber Organization has Little Effect on Electrical Activation Patterns during Focal Arrhythmias in the Left Atrium
论文作者
论文摘要
在过去的二十年中，随着细节水平的增加，发展了心脏传导模型的稳定趋势。但是，由于组织和细胞尺度数据的可用性有限，使模型更现实会使它们的个性化和在临床实践中的使用复杂化。这样的限制是在临床环境中获得有关心肌组织的信息。在这项研究中，我们研究了左心房的嵌合模型，该模型利用临床衍生的患者特异性心房几何形状和对给定患者纤维组织的现实但外国的嵌合模型。我们发现，即使是纤维组织的显着差异，在常规起搏过程中，对时空激活模式的影响相对较小。对于给定的起搏地点，在所有测试的纤维组织中，激活图都非常相似。
Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in clinical practice due to limited availability of tissue and cellular scale data. One such limitation is obtaining information about myocardial fiber organization in the clinical setting. In this study, we investigated a chimeric model of the left atrium utilizing clinically derived patient-specific atrial geometry and a realistic, yet foreign for a given patient fiber organization. We discovered that even significant variability of fiber organization had a relatively small effect on the spatio-temporal activation pattern during regular pacing. For a given pacing site, the activation maps were very similar across all fiber organizations tested.
