论文标题
进化代谢系统的线性响应理论
Linear Response Theory of Evolved Metabolic Systems
论文作者
论文摘要
预测细胞代谢状态是生物物理学中的一个核心问题。但是，传统方法敏感地取决于单个代谢系统的微观细节。在这封信中，我们借助微观经济学理论得出了针对营养条件的代谢反应与代谢抑制之间的普遍线性关系。只要大规模保护定律立足，这种关系就会存在于任意代谢系统中，如广泛的数值计算所支持。它提供定量预测，没有系统的先验知识。
Predicting cellular metabolic states is a central problem in biophysics. Conventional approaches, however, sensitively depend on the microscopic details of individual metabolic systems. In this Letter, we derived a universal linear relationship between the metabolic responses against nutrient conditions and metabolic inhibition, with the aid of a microeconomic theory. The relationship holds in arbitrary metabolic systems as long as the law of mass conservation stands, as supported by extensive numerical calculations. It offers quantitative predictions without prior knowledge of systems.
