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Automated Program Repair (APR) aims to help developers automatically patch software bugs. However, current state-of-the-art traditional and learning-based APR techniques face the problem of limited patch variety, failing to fix complicated bugs. This is mainly due to the reliance on bug-fixing datasets to craft fix templates or directly predict potential patches. Large Pre-Trained Language Models (PLMs), trained using billions of text/code tokens, can potentially help avoid this issue. Very recently, researchers have directly leveraged PLMs for APR without relying on any bug-fixing datasets. Meanwhile, such existing work either failed to include state-of-the-art PLMs or was not evaluated on realistic datasets. In this work, we perform the first extensive study on directly applying PLMs for APR. We select 9 recent state-of-the-art PLMs, including both generative and infilling models, ranging from 125M to 20B in size. We designed 3 different repair settings to evaluate the different ways we can use PLMs to generate patches. We apply the PLMs under these repair settings on 5 datasets across 3 different languages and compare different PLMs in the number of bugs fixed, generation speed and compilation rate. Our study demonstrates that directly applying state-of-the-art PLMs can already substantially outperform all existing APR techniques on all our datasets. Among the studied PLMs, the scaling effect exists for APR where larger models tend to achieve better performance. Also, we show for the first time that suffix code after the buggy line (adopted in infilling-style APR) is important in not only generating more fixes but more patches with higher compilation rate. Besides patch generation, the PLMs consider correct patches to be more natural than other ones, and can even be leveraged for effective patch ranking or patch correctness checking.