论文标题
使用贝叶斯添加期回归树进行审查结果的动态治疗方案
Dynamic Treatment Regimes using Bayesian Additive Regression Trees for Censored Outcomes
论文作者
论文摘要
为了实现为每个患者提供最佳护理的目标,医生需要为具有相同诊断的患者定制治疗,尤其是在治疗可以进一步进展并需要其他治疗的疾病时,例如癌症。可以在多个阶段做出决定作为疾病进展,可以正式化为动态治疗方案(DTR)。在频繁的情况下,开发了大多数现有的用于估计动态治疗方案(包括流行Q学习方法)的优化方法。最近,已经提出了一个通用的贝叶斯机器学习框架,该框架有助于使用贝叶斯回归建模来优化DTR。在本文中,我们将这种方法调整为在加速失败时间建模框架下使用贝叶斯添加剂回归树(BART)的审查结果,以及模拟研究和真实数据示例,将提出的方法与Q-LEARNING进行了比较。我们还开发了R包装功能,该功能利用标准的BART生存模型来优化审查结果的DTR。包装器功能可以轻松扩展以适应任何类型的贝叶斯机器学习模型。
To achieve the goal of providing the best possible care to each patient, physicians need to customize treatments for patients with the same diagnosis, especially when treating diseases that can progress further and require additional treatments, such as cancer. Making decisions at multiple stages as a disease progresses can be formalized as a dynamic treatment regime (DTR). Most of the existing optimization approaches for estimating dynamic treatment regimes including the popular method of Q-learning were developed in a frequentist context. Recently, a general Bayesian machine learning framework that facilitates using Bayesian regression modeling to optimize DTRs has been proposed. In this article, we adapt this approach to censored outcomes using Bayesian additive regression trees (BART) for each stage under the accelerated failure time modeling framework, along with simulation studies and a real data example that compare the proposed approach with Q-learning. We also develop an R wrapper function that utilizes a standard BART survival model to optimize DTRs for censored outcomes. The wrapper function can easily be extended to accommodate any type of Bayesian machine learning model.