论文标题
Picsecond Laser诱导Ti6al4v生物合金上的混合凹槽结构以加速骨整合
Picosecond laser induced hybrid groove structures on Ti6Al4V bio-alloy to accelerate osseointegration
论文作者
论文摘要
调节细胞生长，细胞外基质沉积和人造植入物的矿化是决定体内植入物寿命的一些重要参数。皮秒激光诱导的杂化凹槽结构已显示可改善Ti6al4v生物合金的这些特性。通过改变样品表面上的激光脉冲重叠的程度，在TI6AL4V上产生了两个具有周期性和非周期性子结构的凹槽模式的杂种结构。激光诱导的表面形貌改变，Ti6Al4V的化学成分和润湿性导致羟基磷灰石生长速率增加了3倍，蛋白质吸附吸附率增长了2.5倍，并且与原始样品相比，细胞粘附的增强率为2倍。虽然发现周期性的子结构可以指导细胞生长，但非周期性亚结构提供了同质生长，从而导致底物表面上的整体细胞密度较高。
Regulating cell growth, extracellular matrix deposition and mineralization of artificial implants are some important parameters that decide the longevity of implants in the body. Picosecond laser induced hybrid groove structures have been shown to improve these properties of the Ti6Al4V bio-alloy. Two hybrid structures containing groove patterns with periodic and non-periodic substructures therein were generated on Ti6Al4V by varying the extent of laser pulse overlapping on sample surface. Laser induced alteration in surface topography, chemical composition and wettability of Ti6Al4V resulted in 3-fold increase in the rate of hydroxyapatite growth, 2.5-fold increment in protein adsorption and 2-fold enhancement in cell adhesion in comparison to pristine sample. While the periodic substructure was found to guide cell growth, the non periodic sub structure offered homogenous growth leading to higher overall cell density on the substrate surface.
