论文标题
推断双分子机器中的子系统效率
Inferring Subsystem Efficiencies in Bipartite Molecular Machines
论文作者
论文摘要
在内部传输能量和信息的过程中，由耦合子系统组成的分子机器在不同外部储层之间转换自由能。尽管已经孤立地测量了这些分子机器的子系统效率，但对它们在耦合在一起并共同作用时在自然环境中的表现却较少。在这里，我们得出了两分分子机的子系统效率的上限和下限。我们通过估计$ \ mathrm {f} _ \ mathrm {o} $和$ \ mathrm {f} _1 $ ATP合酶亚基的效率来证明它们的实用性。
Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and information. While subsystem efficiencies of these molecular machines have been measured in isolation, less is known about how they behave in their natural setting when coupled together and acting in concert. Here we derive upper and lower bounds on the subsystem efficiencies of a bipartite molecular machine. We demonstrate their utility by estimating the efficiencies of the $\mathrm{F}_\mathrm{o}$ and $\mathrm{F}_1$ subunits of ATP synthase and that of kinesin pulling a diffusive cargo.
