论文标题
分子记忆代码和突触可塑性：合成
The molecular memory code and synaptic plasticity: a synthesis
论文作者
论文摘要
大脑中最广泛接受的内存视图是，突触是记忆的存储位点，并且通过突触的关联修改来形成记忆。这种观点受到概念和经验理由的挑战。作为替代方案，已经提出，细胞体内的分子是记忆的存储位点，并且通过对这些分子的生化操作形成记忆。本文提出了以记忆计算理论为基础的这两种观点的综合。突触被视为潜在原因近似后概率分布的参数的存储位点。细胞内分子被认为是生成模型参数的存储位点。该理论规定了这两个组件如何作为学习和推论的综合算法的一部分一起工作。
The most widely accepted view of memory in the brain holds that synapses are the storage sites of memory, and that memories are formed through associative modification of synapses. This view has been challenged on conceptual and empirical grounds. As an alternative, it has been proposed that molecules within the cell body are the storage sites of memory, and that memories are formed through biochemical operations on these molecules. This paper proposes a synthesis of these two views, grounded in a computational theory of memory. Synapses are conceived as storage sites for the parameters of an approximate posterior probability distribution over latent causes. Intracellular molecules are conceived as storage sites for the parameters of a generative model. The theory stipulates how these two components work together as part of an integrated algorithm for learning and inference.
