论文标题
在单细胞模型中应用电穿孔时的药物吸收增强
Enhanced drug uptake on application of electroporation in a single-cell model
论文作者
论文摘要
电穿孔方法是将药物输送到人体各种患病组织中的有用工具。由于施加的电场，药物颗粒通过暂时通透的细胞膜进入细胞内室。因此，电穿孔方法可以更好地将药物渗透到患病的组织中，并在临床上改善治疗。在这项研究中，提出了单细胞中更广泛的药物转运模型。由于细胞膜透化不均匀，该模型能够捕获细胞中的非均匀药物转运。进行了几项数值实验，以了解电场和药物渗透性对药物摄取对细胞的影响。通过研究，确定了适当的电场和药物渗透性，从而导致足够的药物吸收细胞。实验者可以使用该模型在进行任何实验之前获取信息，这可能有助于减少可能进行的实际实验数量。
Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized cell membrane. Consequently, electroporation method allows better penetration of the drug into the diseased tissue and improves treatment clinically. In this study, a more generalized model of drug transport in a single-cell is proposed. The model is able to capture non-homogeneous drug transport in the cell due to non-uniform cell membrane permeabilization. Several numerical experiments are conducted to understand the effects of electric field and drug permeability on drug uptake into the cell. Through investigation, the appropriate electric field and drug permeability are identified that lead to sufficient drug uptake into the cell. This model can be used by experimentalists to get information prior to conduct any experiment, and it may help reduce the number of actual experiments that might be conducted otherwise.
