论文标题
膜结构域的形成是通过曲率诱导分子结合/解开两个膜表面的结合/解开的形成
Membrane domain formation induced by binding/unbinding of curvature-inducing molecules onto both membrane surfaces
论文作者
论文摘要
使用网状膜模拟，研究了在热平衡和非平衡稳态中研究曲率诱导分子的结构域形成，例如外周或跨膜蛋白和圆锥形表面活性剂。这些分子可以结合到双层膜的两个表面上，也可以通过触发器移动到相对的传单。在两个传单的对称条件下，除条纹和斑点图案外，膜结构域还形成了棋盘格模式。未结合的膜稳定了棋盘的顶点。在不对称条件下，域形成kagome-lattice和螺纹状域。在非平衡稳态中，上下溶液之间的结合分子的流动可以通过触发器发生。
The domain formation of curvature-inducing molecules, such as peripheral or transmembrane proteins and conical surfactants, is studied in thermal equilibrium and nonequilibrium steady states using meshless membrane simulations. These molecules can bind onto both surfaces of a bilayer membrane and also move to the opposite leaflet by a flip-flop. In symmetric conditions for the two leaflets, the membrane domains form checkerboard patterns in addition to stripe and spot patterns. The unbound membrane stabilizes the vertices of the checkerboard. In asymmetric conditions, the domains form kagome-lattice and thread-like domains. In the nonequilibrium steady states, a flow of the binding molecules between the upper and lower solutions can occur via the flip-flop.
