论文标题
在环形几何形状中限制的粘液模具中动态收缩模式的出现
Emergence of dynamic contractile patterns in slime mold confined in a ring geometry
论文作者
论文摘要
在空间和时间上大尺度上的细胞质流的协调是许多细胞过程的根源，包括生长，迁移或分裂。这些流是由肌动球蛋白皮质的有组织收缩驱动的。为了阐明收缩活性自组织中工作中的基本机制，我们研究了真正的粘液模具中皮质收缩的动态模式\ textit {physarum polycephalum}，这些{Physarum polycephalum}限制在受控几何尺寸的环形腔室中。在没有迁移和增长的情况下，我们详尽地库存了不同稳定的收缩模式。我们表明，振荡的主要频率与环周长无关，而波长则与它线性缩放。我们讨论了这些结果与现有模型的一致性，从而阐明了导致协调收缩活动的可能反馈机制。
Coordination of cytoplasmic flows on large scales in space and time are at the root of many cellular processes, including growth, migration or division. These flows are driven by organized contractions of the actomyosin cortex. In order to elucidate the basic mechanisms at work in the self-organization of contractile activity, we investigate the dynamic patterns of cortex contraction in true slime mold \textit{Physarum polycephalum} confined in ring-shaped chambers of controlled geometrical dimensions. We make an exhaustive inventory of the different stable contractile patterns in the absence of migration and growth. We show that the primary frequency of the oscillations is independent of the ring perimeter, while the wavelength scales linearly with it. We discuss the consistence of these results with the existing models, shedding light on the possible feedback mechanisms leading to coordinated contractile activity.
