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Neuromorphic computing is an emerging research field that aims to develop new intelligent systems by integrating theories and technologies from multi-disciplines such as neuroscience and deep learning. Currently, there have been various software frameworks developed for the related fields, but there is a lack of an efficient framework dedicated for spike-based computing models and algorithms. In this work, we present a Python based spiking neural network (SNN) simulation and training framework, aka SPAIC that aims to support brain-inspired model and algorithm researches integrated with features from both deep learning and neuroscience. To integrate different methodologies from the two overwhelming disciplines, and balance between flexibility and efficiency, SPAIC is designed with neuroscience-style frontend and deep learning backend structure. We provide a wide range of examples including neural circuits Simulation, deep SNN learning and neuromorphic applications, demonstrating the concise coding style and wide usability of our framework. The SPAIC is a dedicated spike-based artificial intelligence computing platform, which will significantly facilitate the design, prototype and validation of new models, theories and applications. Being user-friendly, flexible and high-performance, it will help accelerate the rapid growth and wide applicability of neuromorphic computing research.