论文标题
创造和统一动物的发展和生命阶段本体论
Creation and unification of development and life stage ontologies for animals
论文作者
论文摘要
随着基因组学的新时代，越来越多的动物物种适合大规模数据生成。这导致了新的多物种本体的出现，以注释和组织这些数据。尽管这些努力很好地涵盖了解剖学和细胞类型，但有关开发和生命阶段的信息对于动物数据的注释也至关重要。它的缺乏会阻碍我们回答比较生物学问题并解释功能结果的能力。我们在这里提出了21种动物物种的发展和生命阶段的集合，它们合并为一个常见的多种本体论。这项工作允许在52种动物物种中的转录组数据进行整合和比较。
With the new era of genomics, an increasing number of animal species are amenable to large-scale data generation. This had led to the emergence of new multi-species ontologies to annotate and organize these data. While anatomy and cell types are well covered by these efforts, information regarding development and life stages is also critical in the annotation of animal data. Its lack can hamper our ability to answer comparative biology questions and to interpret functional results. We present here a collection of development and life stage ontologies for 21 animal species, and their merge into a common multi-species ontology. This work has allowed the integration and comparison of transcriptomics data in 52 animal species.
