论文标题

细菌尺寸控制中的多代内存

Multigenerational memory in bacterial size control

论文作者

ElGamel, Motasem, Vashistha, Harsh, Salman, Hanna, Mugler, Andrew

论文摘要

细胞在生长和分裂时保持稳定的尺寸。受可用实验数据的启发,大多数尺寸稳态的模型假设大小控制机制在一代的时间范围内采用。这种机制导致尺寸波动的短暂自相关,衰减不到两代。但是,比较姐妹谱系的最新证据表明,大小波动的相关性可以持续多代。在这里,我们开发了一个最小的模型,该模型解释了这些看似矛盾的结果。我们的模型提出不同的环境会导致不同的控制参数,从而导致不同的继承模式。在恒定环境中揭示了多代内存,但在许多不同的环境上平均时被遮盖。从微流体实验中,从{\ it大肠杆菌}大小数据中推断我们的模型参数,我们概括了观察到的统计数据。我们的工作阐明了环境对细胞体内平衡以及生长和分裂动态的影响。

Cells maintain a stable size as they grow and divide. Inspired by the available experimental data, most proposed models for size homeostasis assume size control mechanisms that act on a timescale of one generation. Such mechanisms lead to short-lived autocorrelations in size fluctuations that decay within less than two generations. However, recent evidence from comparing sister lineages suggests that correlations in size fluctuations can persist for many generations. Here we develop a minimal model that explains these seemingly contradictory results. Our model proposes that different environments result in different control parameters, leading to distinct inheritance patterns. Multigenerational memory is revealed in constant environments but obscured when averaging over many different environments. Inferring the parameters of our model from {\it Escherichia coli} size data in microfluidic experiments, we recapitulate the observed statistics. Our work elucidates the impact of the environment on cell homeostasis and growth and division dynamics.

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