论文标题
具有一维线性阵列的体积图像投影超声超声（VIP-SR）
Volumetric Image Projection Super-Resolution Ultrasound (VIP-SR) with a 1D Unfocused Linear Array
论文作者
论文摘要
已经证明了通过空间分离的微泡通过定位的超声超声（SRU）已被证明可以克服波衍射极限，并在微观尺度上揭示了微血管结构和流动信息。但是，由于2D矩阵阵列探针和连接的制造和计算复杂性，3D SRU成像仍然是一个挑战。受X射线X射线照相的启发，该X射线射线照相可以在单个投影图像中以比X射线CT更简单的硬件呈现体积信息，该研究研究了使用1D未关注的线性阵列的体积图像投影超级分辨率（VIP-SR）超声的可行性。模拟和实验均在3D微血管幻象上使用具有或不具有升高焦点的1D线性阵列以及2D矩阵阵列作为参考。结果表明，与常规的1D高度集中探针相比，使用未关注的1D阵列探针使用未关注的1D阵列探针可以捕获更多的体积信息。与使用具有相同光圈大小的2D阵列探针的完整3D SRUS结果的2D投影图像相比，VIP-SR使用32倍倍的独立元素具有相似的体积覆盖率。还研究了气泡浓度和血管密度对VIP-SR US的影响。这项研究证明了微血管结构的高分辨率体积成像以VIP-SR的成本显着降低。
Super-Resolution Ultrasound (SRUS) through localizing spatially isolated microbubbles has been demonstrated to overcome the wave diffraction limit and reveal the microvascular structure and flow information at the microscopic scale. However, 3D SRUS imaging remains a challenge due to the fabrication and computational complexity of 2D matrix array probes and connections. Inspired by X-ray radiography which can present volumetric information in a single projection image with much simpler hardware than X-ray CT, this study investigates the feasibility of volumetric image projection super-resolution (VIP-SR) ultrasound using a 1D unfocused linear array. Both simulation and experiments were conducted on 3D microvessel phantoms using a 1D linear array with or without an elevational focus, and a 2D matrix array as the reference. Results show that, VIP-SR, using an unfocused 1D array probe can capture significantly more volumetric information than the conventional 1D elevational focused probe. Compared with the 2D projection image of the full 3D SRUS results using the 2D array probe with the same aperture size, VIP-SR has similar volumetric coverage using 32 folds less independent elements. The impact of bubble concentration and vascular density on the VIP-SR US was also investigated. This study demonstrates the ability of high-resolution volumetric imaging of microvascular structures at significantly reduced costs with VIP-SR.
