论文标题
一个分析公式，用于确定单个粘附细胞和传感器底物之间的电阻抗
An Analytical Formula for Determining the Electrical Impedance between a Single Adherent Cell and Sensor Substrate
论文作者
论文摘要
首次提出了使用微电极测量的粘附活细胞和传感器底物之间电阻抗的分析公式。以前报告的公式仅适用于许多电池在大电极上的情况。相比之下，即使小于细胞大小在细胞下方的微电极，我们的公式也是有效的，而最新的单细胞分析通常是这种情况。用于验证我们公式准确性的数值模拟表明，由我们的公式计算出的理论阻抗与数值模拟结果之间的差异明显很小。我们的公式将有助于描述等效电路模型分析或传感器设计优化中的细胞基底阻抗特性。
An analytical formula for electrical impedance between an adherent living cell and sensor substrate measured using a microelectrode is presented for the first time. Previously-reported formula has been applicable only for the case where many cells are on a large electrode. In contrast, our formula is valid even when a microelectrode smaller than the cell size is underneath the cell, which is often the case for the state-of-the-art single-cell analysis. Numerical simulations for verifying the accuracy of our formula reveals that the discrepancies between the theoretical impedances calculated by our formula and numerical simulation results are negligibly small. Our formula will be useful for describing cell-substrate impedance properties in equivalent circuit model analysis or sensor design optimizations.
