论文标题
细胞内信号传导中的物理约束：发送一点的成本
Physical constraints in intracellular signaling: the cost of sending a bit
论文作者
论文摘要
蜂窝系统的主要计算要求之一是能够在空间分离的组件之间传输信息。为了实现这一目标，生物学使用了各种物理通道，包括生产或释放第二门申请人分子和质膜的电去极化。为了发送可靠的信息，这些过程必须耗散能量以与热噪声竞争，在某些情况下，消耗了大部分蜂窝能量预算。在这里，我们使用信息理论中的工具和波动耗散关系来限制几种物理策略进行交流的能量效率，以通过被热噪声损坏的通道来量化通信。我们找到最低的能量成本，以$ k_b $ t/位为$ k_b $ t/l，用于发送信息作为发件人和接收器的大小，空间分离和通信延迟的函数。通过这些计算构建一个相图，指示每个策略最有效的地方。此外，这些计算提供了与细胞环境物理约束有关的信息处理相关的能源成本的估计。
One of the primary computational requirements of a cellular system is the ability to transfer information between spatially separated components. To accomplish this, biology uses diverse physical channels including production or release of second-messengers molecules and electrical depolarization of the plasma membrane. To send reliable information, these processes must dissipate energy to compete with thermal noise, in some cases consuming a substantial fraction of the cellular energy budget. Here we bound the energetic efficiency of several physical strategies for communication, using tools from information theory and the fluctuation dissipation relations to quantify communication through a channel corrupted by thermal noise. We find a minimum energetic cost, in $k_B$T/bit for sending information as a function of the size of the sender and receiver, their spatial separation, and the communication latency. From these calculations construct a phase diagram indicating where each strategy is most efficient. In addition, these calculations provide an estimate for the energy costs associated with information processing arising from the physical constraints of the cellular environment.
