论文标题
量化阿尔茨海默氏病脑电图变化的复杂度度量
Complexity Measures for Quantifying Changes in Electroencephalogram in Alzheimers Disease
论文作者
论文摘要
阿尔茨海默氏病(AD)是一种进展性疾病,会影响认知大脑的功能,并在其临床表现之前多年开始。一种生物标志物,可以定量地衡量大脑因AD在早期阶段而变化的变化,这对于AD的早期诊断很有用,但这将涉及与大量人打交道,因为多达50%的痴呆症患者没有得到正式诊断。因此,需要精确,低成本且易于使用的生物标志物,可用于在早期阶段检测AD。潜在地,基于脑电图(EEG)的生物标志物可以在AD的早期诊断中起着至关重要的作用,因为它们可以满足这些需求。这是一项横断面研究,旨在证明脑电图复杂度度量在早期诊断中的有用性。我们专注于三种复杂性方法,这些方法在检测AD,TSALLIS熵(TSEN),Higuchi分形维度(HFD)和Lempel-Ziv复杂性(LZC)方法方面表现出了最大的希望。与以前的方法不同,在这项研究中,复杂度度量来自EEG频段(而不是整个EEG),因为EEG活动与AD具有显着关联,这导致了性能的增强。结果表明,对于特定的EEG频带和特定的EEG通道,AD患者的TSEN,HFD和LZC值明显降低,并且该信息可用于以敏感性和特异性超过90%来检测AD。
Alzheimers disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the early stages would be useful for early diagnosis of AD, but this would involve dealing with large numbers of people because up to 50% of dementia sufferers do not receive a formal diagnosis. Thus, there is a need for accurate, low-cost, and easy-to-use biomarkers that could be used to detect AD in its early stages. Potentially, electroencephalogram (EEG) based biomarkers can play a vital role in early diagnosis of AD as they can fulfill these needs. This is a cross-sectional study that aims to demonstrate the usefulness of EEG complexity measures in early AD diagnosis. We have focused on the three complexity methods which have shown the greatest promise in the detection of AD, Tsallis entropy (TsEn), Higuchi Fractal Dimension (HFD), and Lempel-Ziv complexity (LZC) methods. Unlike previous approaches, in this study, the complexity measures are derived from EEG frequency bands (instead of the entire EEG) as EEG activities have significant association with AD and this has led to enhanced performance. The results show that AD patients have significantly lower TsEn, HFD, and LZC values for specific EEG frequency bands and for specific EEG channels and that this information can be used to detect AD with a sensitivity and specificity of more than 90%.