论文标题
悬停型：超声图像中无ROI乳腺癌诊断的解剖学感知悬停转换器
HoVer-Trans: Anatomy-aware HoVer-Transformer for ROI-free Breast Cancer Diagnosis in Ultrasound Images
论文作者
论文摘要
Ultrasonography is an important routine examination for breast cancer diagnosis, due to its non-invasive, radiation-free and low-cost properties.但是，由于其固有的局限性，乳腺癌的诊断准确性仍然受到限制。如果我们可以通过乳房超声图像（BUS）精确诊断乳腺癌，那将是一个巨大的成功。已经提出了许多基于学习的计算机辅助诊断方法来实现乳腺癌诊断/病变分类。但是，其中大多数需要预定的ROI，然后对ROI内的病变进行分类。常规的分类骨架，例如VGG16和RESNET50，可以在没有ROI要求的情况下获得有希望的分类结果。但是这些模型缺乏解释性，因此限制了它们在临床实践中的使用。在这项研究中，我们提出了一种具有可解释特征表示的超声图像中乳腺癌诊断的新型无ROI模型。 We leverage the anatomical prior knowledge that malignant and benign tumors have different spatial relationships between different tissue layers, and propose a HoVer-Transformer to formulate this prior knowledge.提出的悬停式跨界块水平和垂直地提取层间和内部空间信息。我们进行并释放开放的数据集GDPH＆SYSUCC，以用于公共汽车中的乳腺癌诊断。 The proposed model is evaluated in three datasets by comparing with four CNN-based models and two vision transformer models via five-fold cross validation.它通过最佳模型可解释性实现最新的分类性能。同时，我们提出的模型在仅给出一张公交图像时，在乳腺癌诊断方面优于两名高级超声检查员。
Ultrasonography is an important routine examination for breast cancer diagnosis, due to its non-invasive, radiation-free and low-cost properties. However, the diagnostic accuracy of breast cancer is still limited due to its inherent limitations. It would be a tremendous success if we can precisely diagnose breast cancer by breast ultrasound images (BUS). Many learning-based computer-aided diagnostic methods have been proposed to achieve breast cancer diagnosis/lesion classification. However, most of them require a pre-define ROI and then classify the lesion inside the ROI. Conventional classification backbones, such as VGG16 and ResNet50, can achieve promising classification results with no ROI requirement. But these models lack interpretability, thus restricting their use in clinical practice. In this study, we propose a novel ROI-free model for breast cancer diagnosis in ultrasound images with interpretable feature representations. We leverage the anatomical prior knowledge that malignant and benign tumors have different spatial relationships between different tissue layers, and propose a HoVer-Transformer to formulate this prior knowledge. The proposed HoVer-Trans block extracts the inter- and intra-layer spatial information horizontally and vertically. We conduct and release an open dataset GDPH&SYSUCC for breast cancer diagnosis in BUS. The proposed model is evaluated in three datasets by comparing with four CNN-based models and two vision transformer models via five-fold cross validation. It achieves state-of-the-art classification performance with the best model interpretability. In the meanwhile, our proposed model outperforms two senior sonographers on the breast cancer diagnosis when only one BUS image is given.
