论文标题
Chetaev的不稳定性框架，用于基于静态依从性的蛋白质展开
Chetaev Instability Framework for Kinetostatic Compliance-Based Protein Unfolding
论文作者
论文摘要
了解蛋白质展开的过程在各种应用中起着至关重要的作用，例如基于折叠的蛋白质发动机的设计。使用良好成熟的动作抑制剂合规性（KCM）的方法来建模蛋白质构象动力学以及最近的非线性控制理论方法，用于基于KCM的蛋白质折叠，该论文将蛋白质制定为蛋白质，作为不稳定的控制控制分析/合成问题。鉴于这种公式，这表明Chetaev不稳定性框架可用于研究基于KCM的展开动力学。特别是，在光学镊子的效果和一类控制Chetaev函数中，用于合成控制输入的chetaev函数，以从其折叠构象中伸出蛋白质链。基于提出的控制Chetaev函数，从Artstein-Sontag通用公式中得出了展开的输入，并将结果与基于光学镊子的展开进行了比较。
Understanding the process of protein unfolding plays a crucial role in various applications such as design of folding-based protein engines. Using the well-established kinetostatic compliance (KCM)-based method for modeling of protein conformation dynamics and a recent nonlinear control theoretic approach to KCM-based protein folding, this paper formulates protein unfolding as a destabilizing control analysis/synthesis problem. In light of this formulation, it is shown that the Chetaev instability framework can be used to investigate the KCM-based unfolding dynamics. In particular, a Chetaev function for analysis of unfolding dynamics under the effect of optical tweezers and a class of control Chetaev functions for synthesizing control inputs that elongate protein strands from their folded conformations are presented. Based on the presented control Chetaev function, an unfolding input is derived from the Artstein-Sontag universal formula and the results are compared against optical tweezer-based unfolding.
