论文标题
在动态稳态中建模简单上皮的现实3D变形
Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
论文作者
论文摘要
在动态稳态期间的组织和器官结构的维持通常不太了解。为了使系统保持稳定，细胞更新，细胞迁移和细胞死亡必须保持精致。此外，组织的形状必须保持相对不变。简单的上皮组织发生在整个体内的各种结构中，例如内皮，间皮，肺部的衬里，唾液和甲状腺腺以及胃肠道。尽管简单的上皮组织流行，但很少有模型准确地描述了这些组织如何保持稳定的结构。 在这里，我们提出了一个简单上皮的小说，3D，可变形，多层，细胞中心模型。细胞运动受上皮，细胞粘附和粘性作用的弯曲电位最小化的控制。我们表明该模型能够在自我更新的同时保持一致的组织结构。我们还证明了该模型在组织更新，细胞迁移和切除细胞下的鲁棒性。此处介绍的模型是对具有复杂和广义结构的组织和器官建模的有价值的进步。
The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell death must be finely balanced. Moreover, a tissue's shape must remain relatively unchanged. Simple epithelial tissues occur in various structures throughout the body, such as the endothelium, mesothelium, linings of the lungs, saliva and thyroid glands, and gastrointestinal tract. Despite the prevalence of simple epithelial tissues, there are few models which accurately describe how these tissues maintain a stable structure. Here, we present a novel, 3D, deformable, multilayer, cell-centre model of a simple epithelium. Cell movement is governed by the minimisation of a bending potential across the epithelium, cell-cell adhesion, and viscous effects. We show that the model is capable of maintaining a consistent tissue structure while undergoing self renewal. We also demonstrate the model's robustness under tissue renewal, cell migration and cell removal. The model presented here is a valuable advancement towards the modelling of tissues and organs with complex and generalised structures.
