论文标题

鼻喷雾雾化的喷雾特性

Spray characteristics from nasal spray atomization

论文作者

Van Strien, James, Petersen, Phred, Lappas, Petros, Yeo, Leslie, Rezk, Amgad, Vahaji, Sara, Inthavong, Kiao

论文摘要

除局部分娩外,鼻喷雾剂还为系统性循环提供了另一种药物管理途径,因此避免了需要痛苦的侵入性递送技术。迄今为止,有关鼻药传递功效的研究仍然存在冲突。特别是计算研究,例如鼻喷雾沉积的计算流体动力学(CFD)需要逼真的初始喷雾条件,这在文献中缺乏。这项研究旨在通过表征在ENT(耳鼻喉喉)诊所中使用的四种不同类型的市售鼻喷雾剂来为CFD输入提供基准实验数据。通过高速摄影获得喷雾特性,而液滴尺寸分布(DSD)测量是通过激光衍射获得的。评估了三个驱动力,代表了平均成人,普通儿童的用例和施加到喷雾装置的最大力量。结果表明,致动力影响喷雾速度,喷雾持续时间,DSD和分解长度。发现了松香 - 雷默直径分布,喷雾锥角,分散角度和分裂长度的定量数据,有助于具有逼真值的计算模型,从而改善了鼻腔中鼻喷雾药物递送的未来CFD研究。

In addition to topical delivery, nasal sprays offer an alternative drug administration route to the systemic circulation, therefore avoiding the need for painful, invasive delivery techniques. Studies on the efficacy of nasal drug delivery to date have been conflicting despite its potential. In particular computational studies, e.g. Computational Fluid Dynamics (CFD), of nasal spray deposition require realistic initial spray conditions, which are lacking in the literature. This study aims to provide benchmark experimental data for CFD inputs by characterising four different types of commercially available nasal sprays used in an ENT (Ear Nose Throat) clinic. Spray characteristics were obtained via high-speed videography, while droplet size distribution (DSD) measurements were obtained with laser diffraction. Three actuation forces were evaluated, representing the use-case of an average adult, average child and the maximum force applied to the spray device. The results demonstrated that actuation force influenced spray velocity, spray duration, DSD, and breakup length. Quantitative data of Rosin-Rammler diameter distributions, spray cone angles, dispersion angles and breakup lengths were found, assisting computational models with realistic values, thereby improving future CFD studies of nasal spray drug delivery in the nasal cavity.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源