论文标题
控制益生菌菌株乳杆菌GG的磁化易感性
Control of magnetic susceptibility of probiotic strain Lactobacillus Rhamnosus GG
论文作者
论文摘要
该论文研究了益生菌微生物的天然磁控制特性的增加，rhamnosus gg（LGG）及其形成磁性敏感夹杂物（MSI）的能力。通过修饰养分培养基组成和在恒定磁场中培养益生菌培养物来提高LGG的磁化率。因此，这项研究可用于进一步用作磁性控制的载体，因为它正在广泛研究癌症治疗中的靶向药物递送，预防化学疗法并发症等。这项研究的结果表明，生长的微生物表明，在静脉内具有较高的静脉内磁性型号的自然磁性特性，并在外部磁场中具有1份磁性型号，并在外部磁性中占据了2 I米的磁性含量，并提高了静脉内的磁性含量。时间分别与对照相比。对于LGG悬浮液，记录了最佳的磁敏感性，该悬浮液在恒定的磁场中生长，并在用螯合物的改性培养基中培养。 LGG悬浮液在恒定的磁场和具有铁螯合物的改良介质上生长，具有最高的磁化率，并且比对照大4.8倍。
The paper investigates the increase in the natural magnetically controlled properties of probiotic microorganisms Lactobacillus rhamnosus GG (LGG) and their ability to form magnetic sensitive inclusions (MsI). The magnetic susceptibility of LGG was increased by modifying the nutrient medium composition and by cultivating the probiotic culture in a constant magnetic field. Therefore, this study can be useful for their further use as magnetically controlled vectors, since it is being extensively researched for the use in targeted drug delivery in cancer treatment, for the prevention of chemotherapy complications, etc. The results of this study indicate that growing microorganisms with natural magnetically-guided properties in a modified medium with iron chelate and in an external magnetic field leads to an increase in the magnetic susceptibility of LGG by 1,8 and 2,6 times, respectively, compared with the control. The best magnetic susceptibility was recorded for LGG suspensions, which were grown in a constant magnetic field and cultured in modified medium with iron chelate. The LGG suspension, grown both in a constant magnetic field and on a modified medium with iron chelate, had the highest magnetic susceptibility and was 4.8 times larger than the control.
