论文标题

高度可扩展的,可穿戴的表面增强拉曼光谱

Highly scalable, wearable surface-enhanced Raman spectroscopy

论文作者

Liu, Limei, Pancorbo, Pablo Martinez, Xiao, Ting-Hui, Noguchi, Saya, Marumi, Machiko, de Pablo, Julia Gala, Karhadkar, Siddhant, Hiramatsu, Kotaro, Segawa, Hiroki, Itoh, Tamitake, Qu, Junle, Takei, Kuniharu, Goda, Keisuke

论文摘要

在过去的二十年中,可穿戴传感器技术的急剧增长,主要由灵活,可拉伸的,皮肤电子传感器表示,可提供佩戴者健康状况和周围环境的丰富信息。该领域的最新突破是基于表面增强的拉曼光谱(SER)的可穿戴化学传感器的发展,该传感器可以普遍,灵敏和无创地检测分子指纹。但是,尽管它们的传感属性非常出色,但由于它们繁琐的制造过程和有限的多功能传感能力,这些传感器不可扩展用于广泛使用的人类健康监测。在这里,我们演示了一个高度可扩展的,可穿戴的SERS传感器,基于易于制作的,低成本,超薄,柔性,可拉伸,粘合剂和生物综合金纳米纳米什(Nanomesh)。它可以以任何形式制造,几乎在任何表面上磨损,以用于从低浓度到高浓度(10 nm-1 mm)的各种分析物的无标签,大规模的原位感测。为了显示可穿戴SERS传感器的实际实用性,我们测试了传感器的检测汗液生物标志物,滥用药物和微塑料。这种可穿戴的SERS传感器代表了朝着可穿戴传感技术的普遍性和实用性迈出的重要一步。

The last two decades have witnessed a dramatic growth of wearable sensor technology, mainly represented by flexible, stretchable, on-skin electronic sensors that provide rich information of the wearer's health conditions and surroundings. A recent breakthrough in the field is the development of wearable chemical sensors based on surface-enhanced Raman spectroscopy (SERS) that can detect molecular fingerprints universally, sensitively, and noninvasively. However, while their sensing properties are excellent, these sensors are not scalable for widespread use beyond small-scale human health monitoring due to their cumbersome fabrication process and limited multifunctional sensing capabilities. Here we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations (10 nM - 1 mM). To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.

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