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A multiplex network of identical dynamical units becomes resilient against parameter perturbation by adding selective linear diffusive cross-coupling links. A parameter drift at any instant in one or multiple network nodes can destroy synchrony, causing failure and even collapse in the network performance. We introduced [PRE 95, 062204(2017)] a recovery strategy by selective addition of cross-coupling links to save synchrony in the network from the edge of failure due to parameter mismatch (small or large) in any nodes. This concept is extended to 2-layered multiplex networks when the emergent synchrony becomes resilient against a small or large parameter drifting. In addition, the stability of the synchronous state is enhanced from local stability to global stability of synchrony. By the addition of cross-coupling, the network revives complete synchrony in all the nodes except the perturbed nodes, which emerges into a type of generalized synchrony with all the unperturbed nodes. The generalized synchrony is manifested simply by a linear amplitude response in the state variable(s) of the perturbed node(s) by a scaling factor proportional to the mismatch. A set of systematic rules has been derived from the linear flow matrix of the dynamical system representing the nodes dynamics that helps find the connectivity matrix of the cross-coupling links. Lyapunov function stability condition is used to determine the cross-coupling link strength that, in turn, establishes global stability of synchrony of the multiplex network. We verify the efficacy of our proposed coupling scheme with analytical results and numerical simulations of two examples of multiplex networks. In the first example, we use non-local connectivity in each layer, with nodal dynamics of the FitzHugh-Nagumo neuron model.