论文标题
超声，光声和磁共振成像捕获的创伤性和血管脑损伤的超急性病理生理学
Hyperacute pathophysiology of traumatic and vascular brain injury captured by ultrasound, photoacoustic, and magnetic resonance imaging
论文作者
论文摘要
大脑创伤性血管损伤后几分钟和几个小时内进化的脑血管动力学和病理机制在很大程度上是未知的。我们研究了小鼠闭合头脑外伤（TBI）和蛛网膜下腔出血（SAH）的头三个小时内的病理生理学演变，这是小鼠的两种常见的外伤性血管损伤。我们使用光声，颜色多普勒和小鼠中的磁共振成像（MRI）采用了多模式成像方法。从基线和SAH之后的基线到15分钟，脑氧合（％SO2）和速度加权的血流量（VVF）值显着降低。 TBI导致19.2％和41.0％的同侧％SO2和VVF减少15分钟，而SAH导致43.9％的SO2和85.0％的VVF降低IPSILEDILLIALLICELALICLAILIAL CHAIMATIOL（P <0.001）。我们发现在TBI受伤后的15分钟到3小时内，我们发现％SO2的部分恢复。在两种模型中受伤后90-150分钟获得的MRI扫描中，出血，水肿，灌注降低和扩散率改变是显而易见的，尽管空间分布主要是TBI的焦点，而SAH的弥漫性。结果表明，受伤后立即发生的大脑％SO2缺陷对于TBI而言是可逆的，而SAH的不可逆。我们的发现可以为未来的研究提供有关减轻这些早期反应以改善长期恢复的研究。
Cerebrovascular dynamics and pathomechanisms that evolve in the minutes and hours following traumatic vascular injury in the brain remain largely unknown. We investigated the pathophysiology evolution within the first three hours after closed-head traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH), two common traumatic vascular injuries, in mice. We took a multi-modal imaging approach using photoacoustic, color Doppler, and magnetic resonance imaging (MRI) in mice. Brain oxygenation (%sO2) and velocity-weighted volume of blood flow (VVF) values significantly decreased from baseline to fifteen minutes after both TBI and SAH. TBI resulted in 19.2% and 41.0% ipsilateral %sO2 and VVF reductions 15 minutes post injury while SAH resulted in 43.9% %sO2 and 85.0% VVF reduction ipsilaterally (p<0.001). We found partial recovery of %sO2 from 15 minutes to 3-hours after injury for TBI but not SAH. Hemorrhage, edema, reduced perfusion, and altered diffusivity were evident from MRI scans acquired 90-150 minutes after injury in both models although the spatial distribution was mostly focal for TBI and diffuse for SAH. The results reveal that the cerebral %sO2 deficits immediately following injuries are reversible for TBI and irreversible for SAH. Our findings can inform future studies on mitigating these early responses to improve long-term recovery.
