论文标题
通过指导提示控制基于蛋白质的模式形成
Control of protein-based pattern formation via guiding cues
论文作者
论文摘要
蛋白质控制活细胞中的许多重要功能，例如细胞生长和细胞分裂。这些功能的可靠协调需要细胞内蛋白质的空间和时间组织，该组织编码有关细胞几何形状和细胞周期阶段的信息。这种蛋白质模式来自蛋白质的转运和反应动力学，可以通过细胞内的各种指导提示来控制它们。在这里，我们回顾了蛋白质模式如何以细胞大小和形状，其他充当模板的蛋白质模式以及细胞的机械性能为指导。参考各种生物模型生物的最新观察结果，阐明了指导模式形成的基本机制。我们认为，了解细胞中蛋白质模式的受控形成将是了解生活系统中信息处理的重要组成部分。
Proteins control many vital functions in living cells, such as cell growth and cell division. Reliable coordination of these functions requires the spatial and temporal organizaton of proteins inside cells, which encodes information about the cell's geometry and the cell-cycle stage. Such protein patterns arise from protein transport and reaction kinetics, and they can be controlled by various guiding cues within the cell. Here, we review how protein patterns are guided by cell size and shape, by other protein patterns that act as templates, and by the mechanical properties of the cell. The basic mechanisms of guided pattern formation are elucidated with reference to recent observations in various biological model organisms. We posit that understanding the controlled formation of protein patterns in cells will be an essential part of understanding information processing in living systems.
