论文标题
使用新结构信息建模细菌鞭毛电动机：两个相互作用的蛋白质纳米环的旋转动力学
Modeling bacterial flagellar motor with new structure information: Rotational dynamics of two interacting protein nano-rings
论文作者
论文摘要
在本文中，我们根据定子综合体最近发现的结构（MOTA $ _5 $ MOTB $ _2 $）开发了旋转细菌鞭毛电动机（BFM）的数学模型。结构表明定子也旋转。 BFM建模为两个相互作用的旋转纳米环。具体而言，质子通过定子复合物的转运驱动了Mota五聚体环的旋转，而Mota五聚体环的旋转又驱动了转子中的圆形环中的Flig环的旋转，并通过定子的Mota环和转子的Flig环之间的相互作用。结构信息模型的初步结果与观察到的扭矩速度关系一致。更重要的是，该模型可以预测独特的转子和定子动力学及其载荷依赖性，这可以通过未来的实验来测试。还讨论了验证和改进模型以进一步了解BFM中扭矩产生的分子机制的可能方法。
In this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA$_5$MotB$_2$). The structure suggested that the stator also rotates. The BFM is modeled as two rotating nano-rings that interact with each other. Specifically, translocation of protons through the stator complex drives rotation of the MotA pentamer ring, which in turn drives rotation of the FliG ring in the rotor via interactions between the MotA ring of the stator and the FliG ring of the rotor. Preliminary results from the structure-informed model are consistent with the observed torque-speed relation. More importantly, the model predicts distinctive rotor and stator dynamics and their load dependence, which may be tested by future experiments. Possible approaches to verify and improve the model to further understanding of the molecular mechanism for torque generation in BFM are also discussed.
