论文标题
预测癌症治疗诱导乳腺癌患者的心脏毒性
Predicting Cancer Treatments Induced Cardiotoxicity of Breast Cancer Patients
论文作者
论文摘要
乳腺癌治疗（即化学疗法，靶向治疗和放射治疗）引起的心脏毒性是乳腺癌患者的重要问题。接受不同疗法的乳腺癌患者的心脏毒性风险尚不清楚。我们使用EHR数据开发并评估了乳腺癌患者心脏毒性的风险预测模型。预测CHF，CAD，CM和MI的AUC得分分别为0.846、0.857、0.858和0.804。在调整了心血管健康的基线差异后，接受化疗或靶向治疗的患者似乎比接受放射治疗的患者具有更高的心脏毒性风险。由于不同乳腺癌治疗组的基线心脏健康的差异，建议在解释这些治疗的心脏毒性作用时谨慎。
Cardiotoxicity induced by the breast cancer treatments (i.e., chemotherapy, targeted therapy and radiation therapy) is a significant problem for breast cancer patients. The cardiotoxicity risk for breast cancer patients receiving different treatments remains unclear. We developed and evaluated risk predictive models for cardiotoxicity in breast cancer patients using EHR data. The AUC scores to predict the CHF, CAD, CM and MI are 0.846, 0.857, 0.858 and 0.804 respectively. After adjusting for baseline differences in cardiovascular health, patients who received chemotherapy or targeted therapy appeared to have higher risk of cardiotoxicity than patients who received radiation therapy. Due to differences in baseline cardiac health across the different breast cancer treatment groups, caution is recommended in interpreting the cardiotoxic effect of these treatments.
