论文标题
接触介导的信号传导可在细胞组件中以疾病驱动的过渡
Contact-mediated signaling enables disorder-driven transitions in cellular assemblies
论文作者
论文摘要
我们表明，当细胞通过接触介导的相互作用传达时，细胞形状和大小的异质性会导致组织中的定性截然不同的集体行为。对于实现侧向抑制的细胞间耦合，这种无序驱动的过渡可以通过邻里几何形状的变化来调节其命运选择，从而显着改变分化细胞的渐近模式。另外，当接触诱导的信号影响固有的细胞振荡时，疾病会导致功能相关的部分阶动态状态的出现。
We show that when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For inter-cellular coupling that implements lateral inhibition, such disorder-driven transitions can substantially alter the asymptotic pattern of differentiated cells by modulating their fate choice through changes in the neighborhood geometry. In addition, when contact-induced signals influence inherent cellular oscillations, disorder leads to the emergence of functionally relevant partially-ordered dynamical states.
