论文标题
沉浸在生物膜上的边界方法扩散在表面
Immersed boundary approach to biofilm spread on surfaces
论文作者
论文摘要
我们提出了一个计算框架，以研究细菌生物膜在界面上的生长和传播以及抗生素对它们的作用。细菌膜由浸入流体基质中的边界表示并受到相互作用的影响。细菌细胞的生长，分裂和死亡遵循动态能量预算规则，这是对细胞释放的养分，毒物和物质的环境浓度的变化。这样，我们创建，破坏和扩大了球形或类似杆的边界。适当的力代表细胞之间相互作用的细节以及与环境的相互作用。数值模拟说明了小生物膜种子的顶视图和直径切片的演变，以及抗生素的作用。我们表明，靶向活性细胞和休眠细胞的抗生素鸡尾酒可以完全消除生物膜。
We propose a computational framework to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces. Growth, division and death of bacterial cells follow dynamic energy budget rules, in response to variations in environmental concentrations of nutrients, toxicants and substances released by the cells. In this way, we create, destroy and enlarge boundaries, either spherical or rod-like. Appropriate forces represent details of the interaction between cells, and the interaction with the environment. Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds, as well as the action of antibiotics. We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.
