论文标题
给编辑的信件和评论：插入动力和相关成像揭示了以扩散为主导的管道和流动性的导管胆剂通量
Letter to the Editor and Comments on: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux
论文作者
论文摘要
胆汁是肝脏的中央代谢产物，由肝细胞分泌为胆汁癌（BC），直径为0.5-2 $ m $ m的管状亚细胞结构，这些结构是由并列肝细胞的顶膜形成的。 BC互连建立一个高度分支的3D网络，该网络将胆汁朝向较大的囊肿间胆管（IBD）。胆汁的运输机制具有根本的兴趣，并且是“渗透口胆管流动”的当前教科书模型，即通过渗透性水流强制执行，基于通量测量和BC收缩性进行了定量验证（Meyer等人，2017年），但在文章中具有挑战性的“植物动态和Corravition Difyernigation Difemitigation Difyernitigations Difemings Difemings Difemings Diffornitiantimentimentimentimentimentimentimentimentimentimentimentimentimentimentimentimentimentiment”。导管胆通”（Vartak等，2020）。我们被迫分享一系列论点，这些论点质疑这项研究的关键结论（Vartak等，2020），特别是因为鉴于潜在的临床应用，它可能会被误解和误导该领域。我们在以下8点中总结了论点。
Bile, the central metabolic product of the liver, is secreted by hepatocytes into bile canaliculi (BC), tubular subcellular structures of 0.5-2 $μ$m diameter which are formed by the apical membranes of juxtaposed hepatocytes. BC interconnect to build a highly ramified 3D network that collects and transports bile towards larger interlobular bile ducts (IBD). The transport mechanism of bile is of fundamental interest and the current text-book model of "osmotic canalicular bile flow", i.e. enforced by osmotic water influx, has recently been quantitatively verified based on flux measurements and BC contractility (Meyer et al., 2017) but challenged in the article entitled "Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux" (Vartak et al., 2020). We feel compelled to share a series of arguments that question the key conclusions of this study (Vartak et al., 2020), particularly because it risks to be misinterpreted and misleading for the field in view of potential clinical applications. We summarized the arguments in the following 8 points.
