学术文献库

Previous work has shown that it is possible to train neuronal cultures on Multi-Electrode Arrays (MEAs), to recognize very simple patterns. However, this work was mainly focused to demonstrate that it is possible to induce plasticity in cultures, rather than performing a rigorous assessment of their pattern recognition performance. In this paper, we address this gap by developing a methodology that allows us to assess the performance of neuronal cultures on a learning task. Specifically, we propose a digital model of the real cultured neuronal networks; we identify biologically plausible simulation parameters that allow us to reliably reproduce the behavior of real cultures; we use the simulated culture to perform handwritten digit recognition and rigorously evaluate its performance; we also show that it is possible to find improved simulation parameters for the specific task, which can guide the creation of real cultures.