论文标题
具有耐药性的脑肿瘤生长的数学模型
Mathematical model of brain tumour growth with drug resistance
论文作者
论文摘要
脑肿瘤是异常细胞的肿块，可以在大脑中以不受控制的方式生长。有不同类型的恶性脑肿瘤。神经胶质瘤是从神经胶质细胞生长的恶性脑肿瘤，被鉴定为星形胶质细胞瘤，寡胶质细胞瘤和性膜瘤。我们研究了描述神经胶质神经元相互作用，神经胶质瘤和化学治疗剂的数学模型。在这项工作中，我们考虑药物敏感和抗性神经胶质瘤细胞。我们表明，连续和脉冲化疗可以杀死神经元的神经元细胞。
Brain tumours are masses of abnormal cells that can grow in an uncontrolled way in the brain. There are different types of malignant brain tumours. Gliomas are malignant brain tumours that grow from glial cells and are identified as astrocytoma, oligodendroglioma, and ependymoma. We study a mathematical model that describes glia-neuron interaction, glioma, and chemotherapeutic agent. In this work, we consider drug sensitive and resistant glioma cells. We show that continuous and pulsed chemotherapy can kill glioma cells with a minimal loss of neurons.
