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We study the effect of cubic and tidal interactions on the spectrum of gravitational waves emitted in the inspiral phase of the merger of two non-spinning objects. There are two independent parity-even cubic interaction terms, which we take to be $I_1 = {R^{αβ}}_{μν} {R^{μν}}_{ρσ} {R^{ρσ}}_{αβ}$ and $G_3 = I_1-2 R^α\,_μ\,^β\,_ν R^μ\,_ρ\,^ν\,_σ R^ρ\,_α\,^σ\,_β$. The latter has vanishing pure graviton amplitudes but modifies mixed scalar/graviton amplitudes which are crucial for our study. Working in an effective field theory set-up, we compute the modifications to the quadrupole moment due to $I_1$, $G_3$ and tidal interactions, from which we obtain the power of gravitational waves radiated in the process to first order in the perturbations and leading order in the post-Minkowskian expansion. The $I_1$ predictions are novel, and we find that our results for $G_3$ are related to the known quadrupole corrections arising from tidal perturbations, although the physical origin of the $G_3$ coupling is unrelated to the finite-size effects underlying tidal interactions. We show this by recomputing such tidal corrections and by presenting an explicit field redefinition. In the post-Newtonian expansion our results are complete at leading order, which for the gravitational-wave flux is 5PN for $G_3$ and tidal interactions, and 6PN for $I_1$. Finally, we compute the corresponding modifications to the waveforms.