论文标题
用于体内药物输送实验的NDFEB永久磁铁配置的优化
Optimization of a NdFeB permanent magnet configuration for in-vivo drug delivery experiments
论文作者
论文摘要
我们提出了一个新的磁焦点概念，用于通过不同的永久磁体的复合构型在活器官中靶向和积累的靶向和积累。拟议的设置满足了体内实验的两个基本要求：1）降低了磁体的大小，以最佳地关注代表小鼠和大鼠靶向器官的小区域，以及2）最大化作用于血液中磁性纳米颗粒上的磁性驱动力。为此，已经测试了具有不同程度的对称性的永久磁体的几种构型。在较大面积（20x20 mm^2）的距离对应于小鼠器官与磁体的假设距离的距离上，已经在广泛的面积（20x20 mm^2）上测量了与磁力成正比的产物B*grad（b）。混合形状永久磁体的非对称配置导致特别有望获得进一步的体内实验的最佳性能。
We propose a new concept of magnetic focusing for targeting and accumulation of functionalized superparamagnetic nanoparticles in living organs through composite configurations of different permanent magnets. The proposed setups fulfill two fundamental requirements for in vivo experiments: 1) reduced size of the magnets to best focusing on small areas representing the targeted organs of mice and rats and 2) maximization of the magnetic driving force acting on the magnetic nanoparticles dispersed in blood. To this aim, several configurations of permanent magnets organized with different degrees of symmetry have been tested. The product B*grad(B) proportional to the magnetic force has been experimentally measured, over a wide area (20x20 mm^2), at a distance corresponding to the hypothetical distance of the mouse organ from the magnets. A non-symmetric configuration of mixed shape permanent magnets resulted in particularly promising to achieve the best performances for further in vivo experiments.
