论文标题
纳米孔捕获棒状分子的流体动力效应
Hydrodynamic effects in the capture of rod-like molecules by a nanopore
论文作者
论文摘要
在生物分子到纳米孔的方法中，必须捕获分子流体动力学各向异性的影响和近壁流体动力相互作用，从而阻碍它们的扩散。我们对带电的纳米孔静电吸引的棒状分子的行为进行了详细的理论分析。我们首先估计与布朗和静电翻译和重新定位相对应的时间尺度。我们发现，在孔隙捕获半径内的距离上，布朗运动变得可以忽略不计，并在数值上确定了该区域中纳米杆的轨迹，以探索各向异性迁移率的影响。这使我们能够确定流体动力相互作用与边界形状的孔的方向范围范围，进近动力学，需要在详细的建模中考虑。
In the approach of biomolecules to a nanopore, it is essential to capture the effects of hydrodynamic anisotropy of the molecules and the near-wall hydrodynamic interactions which hinder their diffusion. We present a detailed theoretical analysis of the behaviour of a rod-like molecule attracted electrostatically by a charged nanopore. We first estimate the time scales corresponding to Brownian and electrostatic translations and reorientation. We find that Brownian motion becomes negligible at distances within the pore capture radius, and numerically determine the trajectories of the nano-rod in this region to explore the effects of anisotropic mobility. This allows us to determine the range of directions from the pore in which hydrodynamic interactions with the boundary shape the approach dynamics and need to be accounted for in detailed modelling.
