论文标题
通过质子交换传递了寄生虫诱导的极化
Parahydrogen-induced polarization relayed via proton exchange
论文作者
论文摘要
NMR和MRI的灵敏度可以通过核自旋的超极化来提高。但是，当前方法是昂贵的，极化相对较低，或者适用性受到限制。在这里，我们报告了一种新的超极化方法，该方法结合了氢化性偏二氢诱导的极化（PHIP）的低成本，高极化，并通过质子交换的极化转移灵活性。新方法可用于极化各种分子，包括醇，水，乳酸和丙酮酸。平均而言，仅$ \ $ 3毫米的超极化转移剂足以通过质子交换显着增强$ \ $ \ $ 100毫米的目标分子的信号。因此，与质子交换（PHIP-X）相关的氢化性偏高诱导的超极化为NMR应用提供了新的途径，超出了热偏振施加的限制。
The sensitivity of NMR and MRI can be boosted via hyperpolarization of nuclear spins. However, current methods are costly, polarization is relatively low, or applicability is limited. Here, we report a new hyperpolarization method combining the low-cost, high polarization of hydrogenative parahydrogen-induced polarization (PHIP) with the flexibility of polarization transfer via proton exchange. The new method can be used to polarize various molecules, including alcohols, water, lactate, and pyruvate. On average, only $\approx$3 mM of a hyperpolarized transfer agent was sufficient to significantly enhance the signal of $\approx$100 mM of target molecules via proton exchange. Thus, hydrogenative parahydrogen-induced hyperpolarization with proton exchange (PHIP-X) provides a new avenue for NMR applications beyond the limits imposed by thermal polarization.
