论文标题
随机过程和宿主 - 寄生虫的进化：连接协同进化动力学和DNA多态性数据
Stochastic processes and host-parasite coevolution: linking coevolutionary dynamics and DNA polymorphism data
论文作者
论文摘要
物种之间的共同进化，特别是拮抗宿主 - 寄生虫共同进化，是一种主要的过程内物种多样性的过程。在本文中，我们研究了影响确定性协调模型结果的各种随机过程的作用。具体而言，我们评估1）遗传漂移和突变对相互作用基因座维持多态性的影响，以及2）由于共同人口统计学的人口学人口大小的变化，这两个共同发展物种的基因组中中性等位基因频率的变化。我们发现，遗传漂移降低了观察经典平衡选择签名的可能性，并且对于共同进化参数的大多数现实值，在主机基因座上看不到平衡选择签名。此外，我们揭示了与经典的期望相反，由于生态evo反馈而引起的寄生虫种群大小的快速变化可以通过在几个时间点测得的等位基因频率频谱跟踪。但是，宿主人群大小的变化不太明显，因此无法观察到。最后，我们还回顾了宿主 - 寄生虫共同进化中发生的几个研究研究的随机过程，这些过程对于预测基础基因座的多态性维持以及宿主和寄生虫种群的全基因组核苷酸多样性至关重要。
Between-species coevolution, and in particular antagonistic host-parasite coevolution, is a major process shaping within-species diversity. In this paper we investigate the role of various stochastic processes affecting the outcome of the deterministic coevolutionary models. Specifically, we assess 1) the impact of genetic drift and mutation on the maintenance of polymorphism at the interacting loci, and 2) the change in neutral allele frequencies across the genome of both coevolving species due to co-demographic population size changes. We find that genetic drift decreases the likelihood to observe classic balancing selection signatures, and that for most realistic values of the coevolutionary parameters, balancing selection signatures cannot be seen at the host loci. Further, we reveal that contrary to classic expectations, fast changes in parasite population size due to eco-evo feedbacks can be tracked by the allelic site-frequency spectrum measured at several time points. Changes in host population size are, however, less pronounced and thus not observable. Finally, we also review several understudied stochastic processes occurring in host-parasite coevolution which are of importance to predict maintenance of polymorphism at the underlying loci and the genome-wide nucleotide diversity of host and parasite populations.
