论文标题
冠状病毒SARS-COV-2基因组中的反复重复序列及其在进化中的影响
Inverted repeats in coronavirus SARS-CoV-2 genome and implications in evolution
论文作者
论文摘要
由冠状病毒SARS-COV-2引起的冠状病毒病（Covid-19）大流行已引起6000万感染和13.8万人死亡。 SARS-COV-2的基因组分析可以提供有关药物设计和疫苗开发的见解，以控制大流行。基因组中的反复重复极大地影响了基因组结构的稳定性并调节基因表达。倒重复涉及细胞进化和遗传多样性，基因组排列和疾病。在这里，我们研究了冠状病毒SARS-COV-2基因组中的倒重复序列。我们发现SARS-COV-2基因组具有丰富的倒重复序列。倒重复序列主要位于峰值蛋白的基因中。因此，该结果表明，峰值蛋白基因经历重组事件，因此对于快速进化至关重要。比较人和蝙蝠冠状病毒中反复重复特征表明SARS-COV-2主要是与SARS相关的冠状病毒，SARSR-COV/RATG13。该研究还表明，最近与SARS相关的冠状病毒SARSR-COV/RMYN02在尖峰蛋白基因中具有大量反转重复序列。此外，这项研究表明，基因组中的反复分布可以视为基因组特征。这项研究强调了反复重复序列在SARS-COV-2的演变中的重要性，并将反复重复列出为基因组分析中的基因组信号。
The coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, has caused 60 millions of infections and 1.38 millions of fatalities. Genomic analysis of SARS-CoV-2 can provide insights on drug design and vaccine development for controlling the pandemic. Inverted repeats in a genome greatly impact the stability of the genome structure and regulate gene expression. Inverted repeats involve cellular evolution and genetic diversity, genome arrangements, and diseases. Here, we investigate the inverted repeats in the coronavirus SARS-CoV-2 genome. We found that SARS-CoV-2 genome has an abundance of inverted repeats. The inverted repeats are mainly located in the gene of the Spike protein. This result suggests the Spike protein gene undergoes recombination events, therefore, is essential for fast evolution. Comparison of the inverted repeat signatures in human and bat coronaviruses suggest that SARS-CoV-2 is mostly related SARS-related coronavirus, SARSr-CoV/RaTG13. The study also reveals that the recent SARS-related coronavirus, SARSr-CoV/RmYN02, has a high amount of inverted repeats in the spike protein gene. Besides, this study demonstrates that the inverted repeat distribution in a genome can be considered as the genomic signature. This study highlights the significance of inverted repeats in the evolution of SARS-CoV-2 and presents the inverted repeats as the genomic signature in genome analysis.
