论文标题
研究体内原发轴的演变和体外
Studying evolution of the primary body axis in vivo and in vitro
论文作者
论文摘要
后代身体计划是在早期胚胎发生期间通过集体细胞重排和进化保守的基因网络建立的，这是通常称为胃肠道的过程的一部分。尽管在表征几种模型生物的胚胎发展方面取得了实质性进展，但许多早期构图过程的基本原理仍然是神秘的。尽管（预 - ）胃胃肠道和成人体形的多样性在整个动物界中，但可以说是最基本特征的身体轴通常在门之间仍然相同。最近，对离体和体外胚胎样系统的重新欣赏，以建模早期的胚胎构图事件。在这里，我们简要审查了关键示例，并提出形态发生以及相关基因表达动力学的相似性可能揭示了进化保守的发育模式，并进一步见解了外部或超晶提示在塑造早期胚胎中的作用。总而言之，我们认为，可以使用类似胚胎的系统来告知动物身体计划演变以及相关模式规则的先前未知方面。
The metazoan body plan is established during early embryogenesis via collective cell rearrangements and evolutionarily conserved gene networks, as part of a process commonly referred to as gastrulation. While substantial progress has been achieved in terms of characterizing the embryonic development of several model organisms, underlying principles of many early patterning processes nevertheless remain enigmatic. Despite the diversity of (pre-)gastrulating embryo and adult body shapes across the animal kingdom, the body axes, which are arguably the most fundamental features, generally remain identical between phyla. Recently there has been a renewed appreciation of ex vivo and in vitro embryo-like systems to model early embryonic patterning events. Here, we briefly review key examples and propose that similarities in morphogenesis as well as associated gene expression dynamics may reveal an evolutionarily conserved developmental mode as well as provide further insights into the role of external or extraembryonic cues in shaping the early embryo. In summary, we argue that embryo-like systems can be employed to inform previously uncharted aspects of animal body plan evolution as well as associated patterning rules.
