论文标题
组合熵行为导致配体 - 受体相互作用的选择性结合范围
Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
论文作者
论文摘要
从病毒到纳米颗粒，用多个配体功能化的构造显示出仅由多价效应引起的特殊结合特性。使用统计机械建模，我们在这里描述了如何利用多价性来实现我们的配音范围选择性，即仅与在指定范围内具有许多受体的靶标结合。我们使用我们的模型来表征参数空间中的区域，其中人们可以期望发生范围选择性目标，并为此现象提供实验支持。总体而言，范围选择性代表了提高多价构建体的靶向选择性的潜在途径。
From viruses to nanoparticles, constructs functionalized with multiple ligands display peculiar binding properties that only arise from multivalent effects. Using statistical mechanical modelling, we describe here how multivalency can be exploited to achieve what we dub range selectivity, that is, binding only to targets bearing a number of receptors within a specified range. We use our model to characterise the region in parameter space where one can expect range selective targeting to occur, and provide experimental support for this phenomenon. Overall, range selectivity represents a potential path to increase the targeting selectivity of multivalent constructs.
