论文标题
注意力缺陷多动障碍的年轻人的结构性大脑不对称
Structural Brain Asymmetries in Youths with Combined and Inattentive Presentations of Attention Deficit Hyperactivity Disorder
论文作者
论文摘要
在注意力缺陷/多动症（ADHD）中，结构性大脑横向性的改变。但是，很少有研究检查了ADHD介绍中的差异。我们从体积，表面积和厚度的解剖学指标中研究了13个皮层和33个皮层区域的不对称指数（AI）。结构性T1加权MRI数据是从注意力不集中（n = 64）且合并（n = 51）的年轻人获得的，并获得了年龄匹配的对照（n = 298）。我们使用了一个线性混合效应模型，该模型解释了数据站点的异质性，同时研究了AI与演示和年龄的协变量之间的关联。我们的论文在ADHD-C和来自ADHD-I的Cingulo-Frontal网络的电动机网络中的ADHD演示中看到的功能结果以及颞皮层和默认模式子网络中的新发现。结构不对称的年龄模式随表现类型而变化。线性混合效应模型是表征大脑不对称，诊断和神经发育之间关联的实用工具。
Alterations in structural brain laterality are reported in attention-deficit/hyperactivity disorder (ADHD). However, few studies examined differences within presentations of ADHD. We investigate asymmetry index (AI) across 13 subcortical and 33 cortical regions from anatomical metrics of volume, surface area, and thickness. Structural T1-weighted MRI data were obtained from youths with inattentive (n = 64) and combined (n = 51) presentations, and aged-matched controls (n = 298). We used a linear mixed effect model that accounts for data site heterogeneity, while studying associations between AI and covariates of presentation and age. Our paper contributes to the functional results seen among ADHD presentations evidencing disrupted connectivity in motor networks from ADHD-C and cingulo-frontal networks from ADHD-I, as well as new findings in the temporal cortex and default mode subnetworks. Age patterns of structural asymmetries vary with presentation type. Linear mixed effects model is a practical tool for characterizing associations between brain asymmetries, diagnosis, and neurodevelopment.
