论文标题
通过两种处理
Power Analysis for Stepped Wedge Trials with Two Treatments
论文作者
论文摘要
阶梯楔设计（SWD）是群集随机试验的设计，这些试验具有交错的单向交叉，通常从对照到治疗条件。有关SWD的统计能力的现有文献主要集中于单一治疗的设计。但是，正在提出和进行多种治疗的SWD。我们为SWD提供了两种处理的线性混合模型，它们之间有和没有相互作用。我们为此类模型的治疗效果系数的标准误差以及功率计算方法得出了封闭形式的解决方案。我们考虑重复的横截面设计以及开放和封闭的队列设计以及不同的随机效应结构。检查设计功能以确定其对主要治疗和相互作用效果的影响的影响。
Stepped wedge designs (SWDs) are designs for cluster randomized trials that feature staggered, unidirectional cross-over, typically from a control to a treatment condition. Existing literature on statistical power for SWDs primarily focuses on designs with a single treatment. However, SWDs with multiple treatments are being proposed and conducted. We present a linear mixed model for a SWD with two treatments, with and without an interaction between them. We derive closed form solutions for the standard errors of the treatment effect coefficients for such models along with power calculation methods. We consider repeated cross-sectional designs as well as open and closed cohort designs and different random effect structures. Design features are examined to determine their impact on power for main treatment and interaction effects.
