论文标题
拆箱突变：将突变类型与进化后果相连
Unboxing mutations: Connecting mutation types with evolutionary consequences
论文作者
论文摘要
突变通常由它们对核苷酸序列的影响及其大小进行分类。在这里，我们认为，如果我们的主要目的是了解突变对进化结果的影响（例如适应或物种形成），我们需要考虑其种群遗传和基因组效应，从改变重组率到修饰染色质。我们首先回顾已知的种群遗传和不同突变类型的基因组效应，然后将其连接到漂移和选择的主要进化过程。我们说明了如何将突变类型与进化结果联系起来，并提供了进一步探索和量化这些关系的建议。这种重新标记为确定不同突变类型的进化意义奠定了基础。
Mutations are typically classified by their effects on the nucleotide sequence and by their size. Here, we argue that if our main aim is to understand the effect of mutations on evolutionary outcomes (such as adaptation or speciation), we need to instead consider their population genetic and genomic effects, from altering recombination rate to modifying chromatin. We start by reviewing known population genetic and genomic effects of different mutation types and connect these to the major evolutionary processes of drift and selection. We illustrate how mutation type can thus be linked with evolutionary outcomes and provide suggestions for further exploring and quantifying these relationships. This reframing lays a foundation for determining the evolutionary significance of different mutation types.
