论文标题

使用腕带可穿戴设备收集的重度症状严重程度与睡眠之间的关系:多中心纵向观察性研究

The Relationship between Major Depression Symptom Severity and Sleep Collected Using a Wristband Wearable Device: Multi-centre Longitudinal Observational Study

论文作者

Zhang, Yuezhou, Folarin, Amos A, Sun, Shaoxiong, Cummins, Nicholas, Ranjan, Rebecca Bendayan Yatharth, Rashid, Zulqarnain, Conde, Pauline, Stewart, Callum, Laiou, Petroula, Matcham, Faith, White, Katie, Lamers, Femke, Siddi, Sara, Simblett, Sara, Myin-Germeys, Inez, Rintala, Aki, Wykes, Til, Haro, Josep Maria, Pennix, Brenda WJH, Narayan, Vaibhav A, Hotopf, Matthew, Dobson, Richard JB

论文摘要

心理健康的研究暗示了抑郁症的睡眠病理学。但是,睡眠评估的黄金标准,多渗透学标准不适用于长期,连续的,对每日睡眠的监测,诸如睡眠日记之类的方法依赖于主观回忆,这是定性和不准确的。另一方面,可穿戴设备提供了一种低成本和方便的手段,可在家庭设置中监视睡眠。这项研究的主要目的是从使用可穿戴设备收集的数据中设计和提取睡眠特征,并分析其与自我评估的患者健康调查表8项目衡量的抑郁症状严重程度和睡眠质量的相关性。每日睡眠数据是通过Fitbit腕带设备被动地收集的,PHQ-8每两周一次自我报告抑郁症状严重程度。本文中使用的数据包括来自来自荷兰,西班牙和英国三个研究地点的368名参与者的2,812个PHQ-8记录。我们从FITBIT数据中提取了21个睡眠功能,这些数据描述了以下五个方面的睡眠:睡眠结构,睡眠稳定性,睡眠稳定性,睡眠质量,睡眠,失眠症和hypersomnia。线性混合回归模型用于探索睡眠特征与抑郁症状严重程度之间的关联。 Z检验用于评估每个特征系数的重要性。我们在整个数据集上测试了我们的模型,并在三个不同研究站点的数据上单独测试了我们的模型。我们确定了16个睡眠特征,这些功能与整个数据集的PHQ-8分数显着相关。睡眠特征与PHQ-8评分之间的关​​联在不同站点之间有所不同,这可能是由于种群的差异。

Research in mental health has implicated sleep pathologies with depression. However, the gold standard for sleep assessment, polysomnography, is not suitable for long-term, continuous, monitoring of daily sleep, and methods such as sleep diaries rely on subjective recall, which is qualitative and inaccurate. Wearable devices, on the other hand, provide a low-cost and convenient means to monitor sleep in home settings. The main aim of this study was to devise and extract sleep features, from data collected using a wearable device, and analyse their correlation with depressive symptom severity and sleep quality, as measured by the self-assessed Patient Health Questionnaire 8-item. Daily sleep data were collected passively by Fitbit wristband devices, and depressive symptom severity was self-reported every two weeks by the PHQ-8. The data used in this paper included 2,812 PHQ-8 records from 368 participants recruited from three study sites in the Netherlands, Spain, and the UK.We extracted 21 sleep features from Fitbit data which describe sleep in the following five aspects: sleep architecture, sleep stability, sleep quality, insomnia, and hypersomnia. Linear mixed regression models were used to explore associations between sleep features and depressive symptom severity. The z-test was used to evaluate the significance of the coefficient of each feature. We tested our models on the entire dataset and individually on the data of three different study sites. We identified 16 sleep features that were significantly correlated with the PHQ-8 score on the entire dataset. Associations between sleep features and the PHQ-8 score varied across different sites, possibly due to the difference in the populations.

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