论文标题
人口界面的形状是共存细胞种群突变不稳定性的指标
Shape of population interfaces as an indicator of mutational instability in coexisting cell populations
论文作者
论文摘要
诸如血管肿瘤和微生物生物膜之类的细胞种群可能会“侵入”或成长为周围种群。入侵人群通常由细胞的异质混合物组成，其生长速率变化。人口还可能表现出突变不稳定性，例如在癌性生长中发生的有害突变负荷。我们研究了异质，突变的人群与周围均匀人群竞争的人群的动力学，正如人们在健康组织的癌症入侵中可能发现的那样。我们发现，人口界面的形状是异质种群进化动力学的指标。特别是，当入侵人群接近突变的崩溃过渡或周围的“旁观者”人口几乎无法重新侵蚀突变人群时，入侵前排起伏就会增强。我们表征了这些界面起伏以及在一维系统中异质种群的有效适应性。
Cellular populations such as avascular tumors and microbial biofilms may "invade" or grow into surrounding populations. The invading population is often comprised of a heterogeneous mixture of cells with varying growth rates. The population may also exhibit mutational instabilities, such as a heavy deleterious mutation load in a cancerous growth. We study the dynamics of a heterogeneous, mutating population competing with a surrounding homogeneous population, as one might find in a cancerous invasion of healthy tissue. We find that the shape of the population interface serves as an indicator for the evolutionary dynamics within the heterogeneous population. In particular, invasion front undulations become enhanced when the invading population is near a mutational meltdown transition or when the surrounding "bystander" population is barely able to reinvade the mutating population. We characterize these interface undulations and the effective fitness of the heterogeneous population in one- and two-dimensional systems.
