论文标题
蛋白质折叠/展开现象起源于瞬时诱导的振荡偶极子的同步/非同步。一个假设
Protein Folding/Unfolding Phenomenon is originated by Synchronization/Desynchronization of Instantaneously Induced Oscillating Dipoles. A Hypothesis
论文作者
论文摘要
蛋白质折叠是一种已经研究了大约50年的现象，仍然是一个未解决的问题。此过程的主要特征是它作为全部或无过程发生，因此蛋白质可以直接在折叠状态和展开状态之间跳跃。在本手稿中提出，与蛋白质折叠相关的合作现象起源于瞬时诱导的偶极子的同步振荡阶段，从而引起了范德华瓦尔斯伦敦分散相互作用。当诱导的偶极子的振荡同步时，触发增强的相互作用状态，并将蛋白质进入折叠过程。在整个分子结构中，该状态的传播完成了折叠过程。如果在任何组件合作网络上引入了足够强大的扰动，则系统进入弱化的（甚至是排斥）的范德华（Van der Wa）的范德华（Van der Wa）的色散相互作用方案，在整个结构中传播自身，从而触发了最终展开蛋白质的相变。
Protein folding is a phenomenon that has been studied for about 50 years and still remains as an unsolved problem. The main feature of this process is that it occurs as an all or none process, so a protein, can jump directly between folded and unfolded states. It is proposed in this manuscript that the cooperative phenomena associated to protein folding has its origin in the synchronization oscillating phases of the instantaneously induced dipoles that gives rise to the van der Waals London dispersion interaction. When the oscillation of the induced dipoles is synchronized an enhanced interaction regime is triggered and the protein enters a into a folding process. The propagation of this regime throughout the molecular structure complete the folding process. If a desynchronizing strong enough perturbation is introduced at any component cooperative network the system enters in a weakened -- or even a repulsive -- van der Waals dispersion interaction regime that propagate itself throughout the structure, that triggers a phase transition that finally unfolds the protein.
