论文标题
高速变异光学分辨率光声显微镜，基于可调声梯度镜头实现较大的景深
High-speed varifocal optical-resolution photoacoustic microscope to achieve large depth of field based on a tunable acoustic gradient lens
论文作者
论文摘要
我们通过使用可调声梯度（TAG）镜头开发了一种能够用高速更换焦平面的光学声学显微镜（OR-PAM）。在我们的系统中，TAG镜头的设计旨在通过快速改变的超声驻波调节其折射功率来连续更改OR-PAM的焦平面。显微镜和激光脉冲的栅格扫描被同步到标签镜头的驱动信号的同一阶段。通过选择同步相，可以在系统中的1.4微秒中以约1毫米的范围选择任意焦平面。由钨电线组成的幻影用于验证系统的变斑能力。进行了体内研究，以进一步证明我们的方法没有任何移动的部分实现了大量的场地（DOF）。
We developed an optical-resolution photoacoustic microscope (OR-PAM) capable of changing focal plane with high-speed by using a tunable acoustic gradient (TAG) lens. In our system, a TAG lens is designed to continuously changing the focal plane of OR-PAM by modulating its refractive power with fast-changing ultrasonic standing wave. The raster-scanning of the microscope and laser pulses are synchronized to the same phase of the driving signal of TAG lens. By selecting the synchronized phase, arbitrary focal plane can be chosen in a range of about 1 millimeter in 1.4 microseconds in our system. A phantom composed by tungsten wires is used to verified the varifocal capability of the system. In-vivo study was carried out, to further demonstrate the large depth-of-field (DoF) achieved by our method without any moving part.
