论文标题
微管细胞骨架的旋转不稳
Swirling Instability of the Microtubule Cytoskeleton
论文作者
论文摘要
在细胞质流的细胞现象中，沿着微管网络携带货物的分子电动机夹带着周围的流体。单个电动机产生的Piconewton力足以使长长的微管变形，许多移动电动机产生的集体流体流也是如此。在果蝇发育过程中的流媒体果蝇$ D $D。为了检验该过渡是由流体结构相互作用驱动的假设，我们研究了一个离散的丝模型和在可变形的细胞骨架上移动的电动机的粗粒粒度模型和粗粒颗粒的连续理论，这两者都显示出$旋转的不稳定性$ to s tossibalientability $ bloctanity的不稳定$，以自发性大规模旋转运动。
In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long microtubules, as are the collective fluid flows generated by many moving motors. Studies of streaming during oocyte development in the fruit fly $D.~melanogaster$ have shown a transition from a spatially-disordered cytoskeleton, supporting flows with only short-ranged correlations, to an ordered state with a cell-spanning vortical flow. To test the hypothesis that this transition is driven by fluid-structure interactions we study a discrete-filament model and a coarse-grained continuum theory for motors moving on a deformable cytoskeleton, both of which are shown to exhibit a $swirling~instability$ to spontaneous large-scale rotational motion, as observed.
