论文标题
通过化学疗法治疗耐药性在肿瘤免疫系统中的影响
Effects of drug resistance in the tumour-immune system with chemotherapy treatment
论文作者
论文摘要
癌症是用于指代大型疾病的术语。癌细胞生长和分裂，因此它们形成大小生长的肿瘤。免疫系统识别癌细胞并攻击它们，但是癌症可能会削弱。一种类型的癌症治疗方法是化学疗法，它使用药物杀死癌细胞。已经开发了临床，实验和理论研究，以了解化学疗法治疗的癌细胞的动力学，以及肿瘤生长与免疫系统之间的相互作用。我们研究了描述癌症生长，免疫系统反应和化学治疗剂的数学模型。免疫系统由静息细胞组成，这些细胞被转化为狩猎细胞以对抗癌症。在这项工作中，我们认为药物敏感和抗性癌细胞。我们表明，肿瘤生长不仅可以通过不同的化学疗法方案来控制，还可以通过攻击敏感和抗性癌细胞的免疫系统来控制。此外，对于所有考虑的方案，我们证明了从静止到狩猎细胞的时间延迟在针对癌细胞的战斗中起着至关重要的作用。
Cancer is a term used to refer to a large set of diseases. The cancerous cells grow and divide and, as a result, they form tumours that grow in size. The immune system recognise the cancerous cells and attack them, though, it can be weakened by the cancer. One type of cancer treatment is chemotherapy, which uses drugs to kill cancer cells. Clinical, experimental, and theoretical research has been developed to understand the dynamics of cancerous cells with chemotherapy treatment, as well as the interaction between tumour growth and immune system. We study a mathematical model that describes the cancer growth, immune system response, and chemotherapeutic agents. The immune system is composed of resting cells that are converted to hunting cells to combat the cancer. In this work, we consider drug sensitive and resistant cancer cells. We show that the tumour growth can be controlled not only by means of different chemotherapy protocols, but also by the immune system that attacks both sensitive and resistant cancer cells. Furthermore, for all considered protocols, we demonstrate that the time delay from resting to hunting cells plays a crucial role in the combat against cancer cells.
